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1

Synthesis and Evaluation of S- and C(1)-Substituted Analogues of Lincomycin

Marie-Pierre Collin, Sven N. Hobbie, Erik C. Böttger, Andrea Vasella

Journal:

Helvetica Chimica Acta

Année:

2009

Langue:

english

Fichier:

PDF, 479 KB

english, 2009

2

The Molecular Basis for A-Site Mutations Conferring Aminoglycoside Resistance: Relationship between Ribosomal Susceptibility and X-ray Crystal Structures

Peter Pfister, Sven Hobbie, Quentin Vicens, Erik C. Böttger, Eric Westhof

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 300 KB

english, 2003

3

Synthesis of 1,2,3-Triazole Analogues of Lincomycin

Marie-Pierre Collin, Sven N. Hobbie, Erik C. Böttger, Andrea Vasella

Journal:

Helvetica Chimica Acta

Année:

2008

Langue:

english

Fichier:

PDF, 242 KB

english, 2008

4

Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket

Katherine S. Long, Jacob Poehlsgaard, Lykke H. Hansen, Sven N. Hobbie, Erik C. Böttger, Birte Vester

Journal:

Molecular Microbiology

Année:

2009

Langue:

english

Fichier:

PDF, 284 KB

english, 2009

5

Glycomics-based analysis of chicken red blood cells provides insight into the selectivity of the viral agglutination assay

Udayanath Aich, Nia Beckley, Zachary Shriver, Rahul Raman, Karthik Viswanathan, Sven Hobbie, Ram Sasisekharan

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2011

6

Humic substance-mediated Fe(III) reduction by a fermenting Bacillus strain from the alkaline gut of a humus-feeding scarab beetle larva

Sven N. Hobbie, Xiangzhen Li, Mirko Basen, Ulrich Stingl, Andreas Brune

Journal:

Systematic and Applied Microbiology

Année:

2012

Langue:

english

Fichier:

PDF, 434 KB

english, 2012

7

Modular glycosphere assays for high-throughput functional characterization of influenza viruses

Hobbie, Sven N, Viswanathan, Karthik, Bachelet, Ido, Aich, Udayanath, Shriver, Zachary, Subramanian, Vidya, Raman, Rahul, Sasisekharan, Ram

Journal:

BMC Biotechnology

Année:

2013

Langue:

english

Fichier:

PDF, 518 KB

english, 2013

8

Conservation of Bacterial Protein Synthesis Machinery: Initiation and Elongation in Mycobacterium smegmatis †

Bruell, Christian M., Eichholz, Carolin, Kubarenko, Andriy, Post, Virginia, Katunin, Vladimir I., Hobbie, Sven N., Rodnina, Marina V., Böttger, Erik C.

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 671 KB

english, 2008

9

Genetic Reconstruction of Protozoan rRNA Decoding Sites Provides a Rationale for Paromomycin Activity against Leishmania and Trypanosoma

Hobbie, Sven N., Kaiser, Marcel, Schmidt, Sebastian, Shcherbakov, Dmitri, Janusic, Tanja, Brun, Reto, Böttger, Erik C., Geary, Timothy G.

Journal:

PLoS Neglected Tropical Diseases

Année:

2011

Langue:

english

Fichier:

PDF, 376 KB

english, 2011

10

N6′, N6′′′, and O4′ Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity

Sati, Girish C., Shcherbakov, Dimitri, Hobbie, Sven N., Vasella, Andrea, Böttger, Erik C., Crich, David

Journal:

ACS Infectious Diseases

Année:

2017

Langue:

english

Fichier:

PDF, 633 KB

english, 2017

11

Preclinical evaluation of VIS513, a therapeutic antibody against dengue virus in non-human primates

Ong, Eugenia Z., Budigi, Yadunanda, Tan, Hwee Cheng, Robinson, Luke N., Rowley, Kirk J., Winnett, Alexander, Hobbie, Sven, Shriver, Zachary, Babcock, Gregory J., Ooi, Eng Eong

Journal:

Antiviral Research

Année:

2017

Langue:

english

Fichier:

PDF, 1.74 MB

english, 2017

12

Structure-Based Design and Synthesis of Apramycin-Paromomycin Analogues. Importance of the Configuration at the 6′-Position and Differences Between the 6′-Amino and Hydroxy Series.

Mandhapati, Appi Reddy, Yang, Guanyu, Kato, Takayuki, Shcherbakov, Dimitri, Hobbie, Sven N., Vasella, Andrea, Böttger, Erik C., Crich, David

Journal:

Journal of the American Chemical Society

Année:

2017

Langue:

english

Fichier:

PDF, 583 KB

english, 2017

13

Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein

Budigi, Yadunanda, Ong, Eugenia Z., Robinson, Luke N., Ong, Li Ching, Rowley, Kirk J., Winnett, Alexander, Tan, Hwee Cheng, Hobbie, Sven, Shriver, Zachary, Babcock, Gregory J., Alonso, Sylvie, Ooi, En

Journal:

PLoS Neglected Tropical Diseases

Année:

2018

Langue:

english

Fichier:

PDF, 6.77 MB

english, 2018

14

Mutation K42R in Ribosomal Protein S12 Does Not Affect Susceptibility of Mycobacterium smegmatis 16S rRNA A-Site Mutants to 2-Deoxystreptamines

Kalapala, Sarath K., Hobbie, Sven N., Böttger, Erik C., Shcherbakov, Dmitry, Tyagi, Anil Kumar

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 405 KB

english, 2010

15

Modification at the 2’-Position of the 4,5-Series of 2-Deoxystreptamine Aminoglycoside Antibiotics to Resist Aminoglycoside Modifying Enzymes and Increase Ribosomal Target Selectivity

Sati, Girish C, Sarpe, Vikram A., Furukawa, Takayuki, Mondal, Sujit, Mantovani, Mathilde, Hobbie, Sven N., Vasella, Andrea, Böttger, Erik C., Crich, David

Journal:

ACS Infectious Diseases

Année:

2019

Langue:

english

Fichier:

PDF, 470 KB

english, 2019

16

Apralogs: Apramycin 5- O -Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant

Quirke, Jonathan C. K., Rajasekaran, Parasuraman, Sarpe, Vikram A., Sonousi, Amr, Osinnii, Ivan, Gysin, Marina, Haldimann, Klara, Fang, Qiao-Jun, Shcherbakov, Dimitri, Hobbie, Sven N., Sha, Su-Hua, Sc

Journal:

Journal of the American Chemical Society

Année:

2019

Fichier:

PDF, 601 KB

2019

17

Epidemiologic, Phenotypic, and Structural Characterization of Aminoglycoside-Resistance Gene aac(3)-IV

Plattner, Michel, Gysin, Marina, Haldimann, Klara, Becker, Katja, Hobbie, Sven N.

Journal:

International Journal of Molecular Sciences

Année:

2020

Fichier:

PDF, 2.20 MB

2020

18

Predictive Analysis of the Side Chain Conformation of the Higher Carbon Sugars: Application to the Preorganization of the Aminoglycoside Ring 1 Side Chain for Binding to the Bacterial Ribosomal Decoding A Site

Pirrone, Michael Gabriel, Gysin, Marina, Haldimann, Klara, Hobbie, Sven N., Vasella, Andrea, Crich, David

Journal:

Journal of Organic Chemistry

Année:

2020

Fichier:

PDF, 449 KB

2020

19

An Advanced Apralog with Increased inâvitro and inâvivo Activity toward Gramânegative Pathogens and Reduced exâvivo Cochleotoxicity

Crich, David, Sonousi, Amr, Quirke, Jonanthan, Waduge, Prabuddha, Janusic, Tanja, Gysin, Marina, Haldimann, Klara, Hobbie, Sven, Sha, Su-Hua, Schacht, Jochen, Christine, Chow, Andrea, Vasella, Bottger

Journal:

Année:

2020

Fichier:

PDF, 1.09 MB

2020